Metastatic inguinal lymph node, squamous and urothelial cell carcinoma in origin: a rare case of carcinoma of unknown primary with two different histopathologic deposits

Abstract

Cancer of unknown primary (CUP) sites constitutes approximately 5% of all cancers.^1,2 The standard treatment for these patients typically involves empirical chemotherapy. However, specific subsets of CUP with unique clinical or pathological features, such as solitary metastatic lesions or isolated nodal CUP, may present a more favourable prognosis and can be effectively managed with excisional surgery or radiation therapy alone.^3-5 Metastatic inguinal lymphadenopathy mainly originates from the genitalia and anorectal areas. In this case report, we describe an uncommon case of two different histological types of metastases in inguinal nodes with unknown primary sites.